steve kirsch fluvoxamine steve kirsch fluvoxamine

On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. Dosage there is 30mg once a day. Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. So there were too few events in the placebo group and they werent recruiting fast enough. I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. Elsewhere he has said he began questioning vaccine safety after an unnamed Twitter follower told him several family members died after getting their shots. I must admit that this is an anniversary that snuck This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). While he declined a phone interview, Boulware was recently the subject of a Mother Jones article about the harassment hes received for his research on hydroxychloroquine and ivermectin. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 7.76K 31 'This Has Cost Millions Of Lives': Steve Kirsch On Suppression Of Repurposed Drugs And A Spike In Deaths 5 Months After Vaccine Rollout By Jan Jekielek American Thought Leaders / The Epoch Times November 24, 2022 Show more The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. Earlier that month, Seftel had heard about fluvoxamine during a presentation by tech entrepreneur Steve Kirsch, whose COVID-19 Early Treatment Fund supports research on existing drugs that could . This advice is now outdated. It was 25 years ago yesterday that Andrew Wakefield launched the modern iteration of the antivaccine movement.In doing so, he laid down a template that antivax quacks today still follow. Telling the truth, he tweeted. P-value was 10^-14 on that study (done by Dr. Always be self aware when using fluvoxamine. Hilary Grant-Valdez Operations Manager Tom Brunner Online. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to completely avoid the list in the previous paragraph, or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). It was approved by the FDA in 1994 and has been used in millions of patients worldwide. I couldnt tell I was on the drug. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. This site requires JavaScript to run correctly. One user reported dilated pupils and increased heart rate (which could be nerves about the dilated pupils). The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. The drug was FDA-approved more than 65 years ago. In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. Now they turn to Rust. Its really, really common for a small effect, something that looks exciting, to be a statistical fluke when you look at a larger population. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. The CDC has advised everyone to wear a mask. Those days are gone. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. Reason is the hospital gets release from liability if they follow NIH guidelines. The NIH wrote a bullshit rejection because the FDA told them not to approve it. Hes probably the closest thing Kirsch has to a nemesis, regularly disputing his assertions in blog posts and private email exchanges with Kirsch and his friends. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. It could do nothing. There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). Physicians who use the drug for COVID now swear by it. Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. Steve Kirsch. Several former members told me he began relentlessly pressuring them to promote the drug in media stories, often during exhausting, circuitous conversations. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. It is not unusual to be wary of developing science, or wrong to be skeptical of pharmaceutical companies. People who report not tolerating the drug are typically prescribed too high a dose. Try refreshing this page and updating them one A few months ago, Kirsch suddenly stopped promoting hydroxychloroquineeven scrubbing it from the CETFs official list of trials it has funded. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. He retired at the largest pension in federal history. If you start later, doctors use higher dosages and compliance becomes a bigger problem. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. customer-service@technologyreview.com with a list of newsletters youd like to receive. I took it myself at that dosage and noticed zero side effects. (article I did after the TOGETHER trial). Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. This looks ominous, but it harmless. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). Its sad, but its true, he told me. In fact, he was unwittingly the source for one of Kirschs figures. It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for the KOL meeting notes to be published because they were rejected by 10 journals. If you were drowning and we had no known standard of care to save your life and someone had a life preserver which worked 160 times in a row, should we throw them the life preserver or let them drown because we aren't absolutely sure the life preserver's benefit > risk (since just because it worked 160 times in a row and there is a 99.99% chance the effect didn't happen by chance, we could have just gotten lucky). Instead, it erodes confidence in our government to provide timely advice that is in the public interest. For decades, coders wrote critical systems in C and C++. YouTube , , , fluvoxamine, , , , , , , , , , Please, As of November 13, fluvoxamine has been proven to work in every trial that has published results, including, studies. I only know of a few doctors who prescribe this off-label, all with 100% success rates. If you take fluvoxamine, please avoid caffeine while on the drug. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. CETF Founder Steve Kirsch discusses why we can't wait for a COVID-19 vaccine, the importance of researching existing drugs now, and our work to raise funds for outpatient trials to identify effective . I've collected fluvoxamine evidence here for convenient access. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. Long haul. Steve is a Silicon Valley entrepreneur and philanthropist who founded the COVID-19 Early Treatment Fund (CETF) at the beginning of the pandemic. The medical community did nothing (with a few exceptions like Dr. Seftel). 19 In addition, several . Although there is evidence that fluvoxamine can prevent clinical worsening and the need for hospitalizations in outpatients with early covid-19, I have seen no good evidence that fluvoxamine is useful as a substitute for the vaccines, co-investigator Angela Reiersen wrote to me. The US government accused Janssen of improperly promoting the antipsychotic drug Risperdal to dementia patients despite the drug increasing deaths in the elderly. In short, a lot of mumbo jumbo. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. I fixed the link to the fluvoxamine article. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). All have had a 100% success record in keeping their patients out of the hospital. . After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. Note that a total of 77 people got the drug, not 65. When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. The medical community did nothing (with a few exceptions like Dr. Seftel). The reason that it isnt used is because the medical community ignores evidence-based medicine principles. If you start 5 days after symptoms, all bets are off. But fear of trying something new prevents any doctor from giving this drug a try. . $1M reward: Do we need more data re: Fluvoxamine for COVID-19? 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. I disagree with his interpretation of the data regarding several medicines and strongly disagree with his anti-vaccine nonsense, Boulware wrote to me. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? MisinformationKills. Once the Phase 2 result came out, it should have been embraced by doctors. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. Several other trials around the world are in the final stages, too. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. 33. JAMA systematic review and meta analysis It doesnt get any better than this. Another CETF grant, though, yielded far more exciting results. . Have the drug on hand. Proven in clinical use all over the world. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. It does not matter how many lives will be saved. Its the gold standard of medical evidence. My favorite dosage is 50mg twice a day for 14 days. I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. Links to evidence about fluvoxamine including the public data repository. 21. Those days are gone. See this Wall Street Journal op-ed. These people never called the researchers whose trials they claimed showed no effect. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. Fluvoxamine was reportedly added to just 2 practice guidelines (Ontario and Johns Hopkins). The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). (Clayton Fox, Marty Makary, and Jeffrey Klausner). Summarizes the 5 observational studies, RCT, RWE, and some of the more interesting anecdotal data. We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. skirsch.io Steve Kirsch Home page. His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. [NIH] doesnt want any of these treatments. Kirsch and his wife, Michele, fund a charitable foundation, which by 2007 had given $75 million to different causes. But Kirsch is also motivated by an unsatisfied competitive streak. , or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). So it was both obvious and convincing the difference between the groups to the workers and the track management. He is the inventor of the optical mouse and one of the first Internet search engines, Infoseek. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. While combining the results of several well-designed trials can strengthen an argument or unearth patterns unseen in smaller samples, a meta-analysis is just the sum of its parts; any single well-done experiment is more useful than combining the results of several poorly done ones. He says that Facebook took down one of his posts announcing his appearance on 60 Minutes. Steve Kirsch is looking for an explanation for 171,000 excess deaths. In some cases, youd want to taper down the dosage. In-patient use. Medium revoked my account for life. Its motivated out of his sense of keeping people safe and advancing health care.. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). A very short op-ed arguing for using fluvoxamine against COVID. Author Affiliations . We could have saved a lot of lives. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. Thanks for working tirelessly to help others. I was just getting tired, he said, before asking to speak off the record. 95% confidence effect size is 75% or more. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. The only way to do that is to treat them as early as possible with a drug that prevents hospitalization and death. Online Status. From the French observational data (see the very last page), it appears that the biggest effect is limiting serotonin release (any SSRI will do that). Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. The medical community doesnt care about saving lives. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. Why not fluvoxamine? The data is there in plain sight for anyone to see today. Author Affiliations Article Information. If there is a better drug on the table today than fluvoxamine, the NIH panel should put that one on the guidelines. This is what the Seftel trial at Golden Gate fields used. committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes, This site requires JavaScript to run correctly. We dont want to feed the anti-vaccine trolls, so we actively suppress clear scientific data. The paramedics will think you are on drugs. Or just depression about the vaccine mandates? I mean, he really, truly has a heart of gold, Char told me. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. So you can address your OCD and if you get COVID, youll can up the dose. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. Thats pretty typical, but your mileage may vary. But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. . Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. Online. The post read: "I will be featured on 60 Minutes this Sunday talking about fluvoxamine as an effective treatment for COVID-19 to prevent hospitalization and death. I wanted to get the article out before my flight left. This document is a collection of evidence that highlights the glaring errors in our pandemic response. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel, this is NOT about the science. The NIH wrote a bullshit rejection because the FDA told them not to approve it. So far, doctors have failed to share his sense of urgency. Food/drugs to avoid while on fluvoxamine. Who knows, Morris replied. My favorite dosage is 50mg twice a day for 14 days. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. In other cases, stop cold turkey. My crime? This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. There are 4 outpatient studies that have been done (2 at WashU (see Phase 2 trial results published in JAMA), one in Berkeley, CA by David Seftel, one in Brazil published in the Lancet, and one in-patient study done in Croatia. Talking to Kirsch is an exhausting experience. The NIH never did a risk benefit analysis of this drug. Steve Kirsch said scientists and clinicians are studying a host of drugs and therapeutics to create a new line of defence against the virus but clinical trials are yet to lead to conclusive. One Silicon Valley entrepreneur thought he could beat the odds. Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. . To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. Everyone is stunned, but nobody is surprised. I couldn't agree more. saying that the per-protocol analysis was arbitrary and other excuses. Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). Its actually much harder to parse out a signal than if youre treating diabetes or cancer., In addition to the issues with fluvoxamine, advisors grew increasingly uncomfortable with Kirschs posts about ivermectin, which he has repeatedly claimed in blog posts and appearances in alternative media can be used together with fluvoxamine to prevent 100% of covid-19 deaths. Ivermectin and fluvoxamine have been confirmed in Phase 3 trials. Kirsch IDeacon BJHuedo-Medina TBScoboria AMoore TJJohnson BT Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines.